abstract：:St. John's wort (SJW, Hypericum perforatum) is one of the popular nutraceuticals for treating depression. Methotrexate (MTX) is an immunosuppressant with narrow therapeutic window. This study investigated the effect of SJW on MTX pharmacokinetics in rats. Rats were orally given MTX alone and coadministered with 300 an...

journal_title：Toxicology and applied pharmacology

authors： Yang SY,Juang SH,Tsai SY,Chao PD,Hou YC

更新日期：2012-08-15 00:00:00

abstract：:The present investigation was undertaken to study if curcumin, which is recognized for its potential as an antineoplastic and immunopotentiating agent, can also influence the process of myelopoiesis in a tumor-bearing host. Administration of curcumin to tumor-bearing host augmented count of bone marrow cell (BMC) acco...

journal_title：Toxicology and applied pharmacology

authors： Vishvakarma NK,Kumar A,Kumar A,Kant S,Bharti AC,Singh SM

更新日期：2012-08-15 00:00:00

abstract：:CIL-102 (1-[4-(furo[2,3-b]quinolin-4-ylamino)phenyl]ethanone) is the major active agent of the alkaloid derivative of Camptotheca acuminata, with multiple pharmacological activities, including anticancer effects and promotion of apoptosis. The mechanism by which CIL-102 inhibits growth remains poorly understood in hum...

journal_title：Toxicology and applied pharmacology

authors： Teng CC,Kuo HC,Cheng HC,Wang TC,Sze CI

更新日期：2012-08-15 00:00:00

abstract：:Published toxicology data on chitosan nanoparticles (NP) often lack direct correlation to the in situ size and surface characteristics of the nanoparticles, and the repeated NP assaults as experienced in chronic use. The aim of this paper was to breach these gaps. Chitosan nanoparticles synthesized by spinning disc pr...

journal_title：Toxicology and applied pharmacology

authors： Loh JW,Saunders M,Lim LY

更新日期：2012-08-01 00:00:00

abstract：:Calcium channel blockers (CCBs) are important in the management of hypertension and limit restenosis. Although CCB efficacy could derive from decreased blood pressure, other mechanisms independent of CCB activity also can contribute to antiproliferative action. To understand mechanisms of CCB-mediated antiproliferatio...

journal_title：Toxicology and applied pharmacology

authors： Salabei JK,Balakumaran A,Frey JC,Boor PJ,Treinen-Moslen M,Conklin DJ

更新日期：2012-08-01 00:00:00

abstract：:Recent breakthroughs in stem cell biology, especially the development of the induced pluripotent stem cell techniques, have generated tremendous enthusiasm and efforts to explore the therapeutic potential of stem cells in regenerative medicine. Stem cell therapies are being considered for the treatment of degenerative...

journal_title：Toxicology and applied pharmacology

authors： Sharpe ME,Morton D,Rossi A

更新日期：2012-08-01 00:00:00

abstract：:Arsenic ingestion has been linked to increasing global prevalence of and mortality from cardiovascular disease (CVD); arsenic can be removed from drinking water to reduce related health effects. Lactate dehydrogenase (LDH) is used for the evaluation of acute arsenic toxicity in vivo and in vitro, but it is not validat...

journal_title：Toxicology and applied pharmacology

authors： Liao YT,Chen CJ,Li WF,Hsu LI,Tsai LY,Huang YL,Sun CW,Chen WJ,Wang SL

更新日期：2012-08-01 00:00:00

abstract：:Studies in recent years have revealed that excess mitochondrial superoxide production is an important etiological factor in neurodegenerative diseases, resulting from oxidative modifications of cellular lipids, proteins, and nucleic acids. Hence, it is important to understand the mechanism by which mitochondrial oxida...

journal_title：Toxicology and applied pharmacology

authors： Fukui M,Choi HJ,Zhu BT

更新日期：2012-07-15 00:00:00

abstract：:Dasatinib, a multitargeted inhibitor of BCR-ABL and SRC kinases, exhibits antitumor activity and extends the survival of patients with chronic myeloid leukemia (CML) and Philadelphia chromosome-positive acute lymphoblastic leukemia (ALL). However, some patients suffer from hepatotoxicity, which occurs through an unkno...

journal_title：Toxicology and applied pharmacology

authors： Xue T,Luo P,Zhu H,Zhao Y,Wu H,Gai R,Wu Y,Yang B,Yang X,He Q

更新日期：2012-06-15 00:00:00

abstract：:Emerging evidence suggests that feeding a high-fat diet (HFD) to rodents affects the expression of genes involved in drug transport. However, gender-specific effects of HFD on drug transport are not known. The multidrug resistance-associated protein 2 (Mrp2, Abcc2) is a transporter highly expressed in the hepatocyte c...

journal_title：Toxicology and applied pharmacology

authors： Kong B,Csanaky IL,Aleksunes LM,Patni M,Chen Q,Ma X,Jaeschke H,Weir S,Broward M,Klaassen CD,Guo GL

更新日期：2012-06-01 00:00:00

abstract：:Embryo implantation is a crucial step in human reproduction and depends on the timely development of a receptive endometrium. The human endometrium is unique among adult tissues due to its dynamic alterations during each menstrual cycle. It hosts the implantation process which is governed by progesterone, whereas 17β-...

journal_title：Toxicology and applied pharmacology

authors： Fischer L,Deppert WR,Pfeifer D,Stanzel S,Weimer M,Hanjalic-Beck A,Stein A,Straßer M,Zahradnik HP,Schaefer WR

更新日期：2012-05-01 00:00:00

abstract：:This study defines a physiologically based kinetic (PBK) model for methyleugenol (ME) in human based on in vitro and in silico derived parameters. With the model obtained, bioactivation and detoxification of methyleugenol (ME) at different doses levels could be investigated. The outcomes of the current model were comp...

journal_title：Toxicology and applied pharmacology

authors： Al-Subeihi AA,Spenkelink B,Punt A,Boersma MG,van Bladeren PJ,Rietjens IM

更新日期：2012-05-01 00:00:00

abstract：:There is concern that P-glycoprotein mediated efflux contributes to steroid resistance. Therefore, this study examined bidirectional corticosteroid transport and induction capabilities for P-glycoprotein (P-gp) to understand which of the systemic and inhaled corticosteroids interacted with P-gp to the greatest extent....

journal_title：Toxicology and applied pharmacology

authors： Crowe A,Tan AM

更新日期：2012-05-01 00:00:00

abstract：:Investigations have characterized addictive drug-induced developmental cardiovascular malformation in human, non-human primate and rodent. However, the underlying mechanism of malformation caused by drugs during pregnancy is still largely unknown, and preventive and therapeutic measures have been lacking. Using 1H NMR...

journal_title：Toxicology and applied pharmacology

authors： Shao X,Hu Z,Hu C,Bu Q,Yan G,Deng P,Lv L,Wu D,Deng Y,Zhao J,Zhu R,Li Y,Li H,Xu Y,Yang H,Zhao Y,Cen X

更新日期：2012-05-01 00:00:00

abstract：:Propiconazole is a mouse hepatotumorigenic fungicide designed to inhibit CYP51, a key enzyme in the biosynthesis of ergosterol in fungi and is widely used in agriculture to prevent fungal growth. Metabolomic studies in mice revealed that propiconazole increased levels of hepatic cholesterol metabolites and bile acids,...

journal_title：Toxicology and applied pharmacology

authors： Murphy LA,Moore T,Nesnow S

更新日期：2012-04-15 00:00:00

abstract：:Polycyclic Aromatic Hydrocarbons (PAHs) constitute a family of over one hundred compounds and can generally be found in complex mixtures. PAHs metabolites cause DNA damage which can lead to the development of carcinogenesis. Toxicity assessment of PAH complex mixtures is currently expressed in terms of toxic equivalen...

journal_title：Toxicology and applied pharmacology

authors： Audebert M,Zeman F,Beaudoin R,Péry A,Cravedi JP

更新日期：2012-04-01 00:00:00

abstract：:Therapy of seizure activity following exposure to the nerve agent soman (GD) includes treatment with the anticonvulsant diazepam (DZP), an allosteric modulator of γ-aminobutyric acid A (GABA(A)) receptors. However, seizure activity itself causes the endocytosis of GABA(A) receptors and diminishes the inhibitory effect...

journal_title：Toxicology and applied pharmacology

authors： Schultz MK,Wright LK,Stone MF,Schwartz JE,Kelley NR,Moffett MC,Lee RB,Lumley LA

更新日期：2012-03-15 00:00:00

abstract：:Lipid rafts are microdomains of the plasma membrane enriched in cholesterol and sphingolipids, and play an important role in the initiation of many pharmacological agent-induced signaling pathways and toxicological effects. The structure of lipid rafts is dynamic, resulting in an ever-changing content of both lipids a...

journal_title：Toxicology and applied pharmacology

authors： George KS,Wu S

更新日期：2012-03-15 00:00:00

abstract：:Male Wistar rats exposed to a systemic organophosphorus insecticide, phorate [O,O-diethyl S-[(ethylthio) methyl] phosphorothioate] at varying oral doses of 0.046, 0.092 or 0.184mg phorate/kg bw for 14days, exhibited substantial oxidative stress, cellular DNA damage and activation of apoptosis-related p53, caspase 3 an...

journal_title：Toxicology and applied pharmacology

authors： Saquib Q,Attia SM,Siddiqui MA,Aboul-Soud MA,Al-Khedhairy AA,Giesy JP,Musarrat J

更新日期：2012-02-15 00:00:00

abstract：:Increased oxygen species production has often been cited as a mechanism determining synergism on cell death and growth inhibition effects of arsenic-combined drugs. However the net effect of drug combination may not be easily anticipated solely from available knowledge of drug-induced death mechanisms. We evaluated th...

journal_title：Toxicology and applied pharmacology

authors： Lombardo T,Cavaliere V,Costantino SN,Kornblihtt L,Alvarez EM,Blanco GA

更新日期：2012-02-01 00:00:00

abstract：:Our previous studies in mice revealed that two weeks short-term toxicity of sodium selenosulfate was significantly lower than that of sodium selenite, but selenium repletion efficacy of both compounds was equivalent. In addition, we showed that sodium selenosulfate reduced nephrotoxicity of cisplatin (CDDP) without co...

journal_title：Toxicology and applied pharmacology

authors： Li J,Sun K,Ni L,Wang X,Wang D,Zhang J

更新日期：2012-02-01 00:00:00

abstract：:Inhaling concomitants from Asian sand dust (ASD) may result in exacerbation of pneumonia by the pathogen. The exacerbating effect of ASD on pneumonia induced by Klebsiella pneumoniae (KP) was investigated in ICR mice. The organic substances adsorbed onto ASD collected from the atmosphere of Iki-island in Japan were ex...

journal_title：Toxicology and applied pharmacology

authors： He M,Ichinose T,Yoshida S,Yamamoto S,Inoue K,Takano H,Yanagisawa R,Nishikawa M,Mori I,Sun G,Shibamoto T

更新日期：2012-01-15 00:00:00

abstract：:Mechanisms of cyclosporine A (CsA)-induced nephrotoxicity were generally thought to be hemodynamic in origin; however, there is now accumulating evidence of a direct tubular effect. Although genomic and proteomic experiments by our group and others provided overall information on genes and proteins up- or down-regulat...

journal_title：Toxicology and applied pharmacology

authors： Sarró E,Jacobs-Cachá C,Itarte E,Meseguer A

更新日期：2012-01-15 00:00:00

abstract：:The neuroblastoma-spinal motor neuron fusion cell line, NSC-34, in its differentiated form, NSC-34D, permits examining the effects of riluzole, a proven treatment for amyotrophic lateral sclerosis (ALS) on cell death induction by staurosporine (STS), thapsigargin (Thaps), hydrogen peroxide (H(2)O(2)) and homocysteine ...

journal_title：Toxicology and applied pharmacology

authors： Hemendinger RA,Armstrong EJ 3rd,Radio N,Brooks BR

更新日期：2012-01-15 00:00:00

abstract：:It is postulated that nicotine, as the main neurotoxic constituent of cigarette smoke, influences SIDS risk through effects on nicotinic acetylcholine receptors (nAChRs) in brainstem nuclei that control respiration and arousal. This study compared α7 and β2 nAChR subunit expression in eight nuclei of the caudal and ro...

journal_title：Toxicology and applied pharmacology

authors： Machaalani R,Say M,Waters KA

更新日期：2011-12-15 00:00:00

abstract：:Our recent study demonstrated the increased risk of renal cell carcinoma (RCC) associated with high urinary total arsenic levels among people living in a low arsenic exposure area. Genomic instability is important in arsenic carcinogenesis. This study evaluated the relationship between the polymorphisms of p53, p21, a...

journal_title：Toxicology and applied pharmacology

authors： Huang CY,Su CT,Chu JS,Huang SP,Pu YS,Yang HY,Chung CJ,Wu CC,Hsueh YM

更新日期：2011-12-15 00:00:00

abstract：:Juglone is a phenolic compound used in popular medicine as a phytotherapic to treat inflammatory and infectious diseases. However, it also acts as an uncoupler of oxidative phosphorylation in isolated liver mitochondria and, thus, may interfere with the hepatic energy metabolism. The purpose of this work was to evalua...

journal_title：Toxicology and applied pharmacology

authors： Saling SC,Comar JF,Mito MS,Peralta RM,Bracht A

更新日期：2011-12-15 00:00:00

abstract：:WHO has highlighted the need to evaluate dermal toxicity of mycotoxins including Patulin (PAT), detected in several fruits. In this study the skin carcinogenic potential of topically applied PAT was investigated. Single topical application of PAT (400 nmol) showed enhanced cell proliferation (~2 fold), along with incr...

journal_title：Toxicology and applied pharmacology

authors： Saxena N,Ansari KM,Kumar R,Chaudhari BP,Dwivedi PD,Das M

更新日期：2011-12-01 00:00:00

abstract：BACKGROUND AND PURPOSE:Arsenic exposure frequently leads to reproductive failures by disrupting the rat uterine histology, hormonal integrity and estrogen signaling components of the rat uterus, possibly by generating reactive oxygen species. All-trans retinoic acid (ATRA) was assessed as a prospective therapeutic agen...

journal_title：Toxicology and applied pharmacology

authors： Chatterjee A,Chatterji U

更新日期：2011-12-01 00:00:00

abstract：:Petroleum-derived compounds, including polycyclic aromatic hydrocarbons (PAHs), commonly occur as complex mixtures in the environment. Recent studies using the zebrafish experimental model have shown that PAHs are toxic to the embryonic cardiovascular system, and that the severity and nature of this developmental card...

journal_title：Toxicology and applied pharmacology

authors： Incardona JP,Linbo TL,Scholz NL

更新日期：2011-12-01 00:00:00

abstract：:Diethyl hexyl phthalate (DEHP) is an endocrine disruptor, it influences various organ systems in human beings and experimental animals. DEHP reduced the serum testosterone and increased the blood glucose, estradiol, T(3) and T(4) in rats. However, the effect of DEHP on insulin signaling and glucose oxidation in skelet...

journal_title：Toxicology and applied pharmacology

authors： Srinivasan C,Khan AI,Balaji V,Selvaraj J,Balasubramanian K

更新日期：2011-12-01 00:00:00

abstract：:4-Chlorotetrazolo[1,5-a]quinoxaline is a quinoxaline derivative. We aimed to study the effects of 4-chlorotetrazolo[1,5-a]quinoxaline on activation of mast cells in vitro and in mice. 4-Chlorotetrazolo[1,5-a]quinoxaline reversibly inhibited degranulation of mast cells in a dose-dependent manner, and also suppressed th...

journal_title：Toxicology and applied pharmacology

authors： Park KL,Ko NY,Lee JH,Kim DK,Kim HS,Kim AR,Her E,Kim B,Kim HS,Moon EY,Kim YM,Kim HR,Choi WS

更新日期：2011-12-01 00:00:00

abstract：:Genome-wide, promoter-focused ChIP-chip analysis of hepatic aryl hydrocarbon receptor (AHR) binding sites was conducted in 8-week old female C57BL/6 treated with 30 μg/kg/body weight 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD) for 2 h and 24 h. These studies identified 1642 and 508 AHR-bound regions at 2h and 24h, resp...

journal_title：Toxicology and applied pharmacology

authors： Lo R,Celius T,Forgacs AL,Dere E,MacPherson L,Harper P,Zacharewski T,Matthews J

更新日期：2011-11-15 00:00:00

abstract：:Exposure of human bladder urothelial cells (UROtsa) to 50 nM of the arsenic metabolite, monomethylarsonous acid (MMA(III)), for 12 weeks results in irreversible malignant transformation. The ability of continuous, low-level MMA(III) exposure to cause an increase in genotoxic potential by inhibiting repair processes ne...

journal_title：Toxicology and applied pharmacology

authors： Wnek SM,Kuhlman CL,Camarillo JM,Medeiros MK,Liu KJ,Lau SS,Gandolfi AJ

更新日期：2011-11-15 00:00:00

abstract：:Exposure to excessive manganese (Mn) levels leads to neurotoxicity, referred to as manganism, which resembles Parkinson's disease (PD). Manganism is caused by neuronal injury in both cortical and subcortical regions, particularly in the basal ganglia. The basis for the selective neurotoxicity of Mn is not yet fully un...

journal_title：Toxicology and applied pharmacology

authors： Milatovic D,Gupta RC,Yu Y,Zaja-Milatovic S,Aschner M

更新日期：2011-11-01 00:00:00

abstract：:Motor neuron disease is a devastating neurodegenerative condition, with the majority of sporadic, non-familial cases being of unknown etiology. Several epidemiological studies have suggested that occupational exposure to chemicals may be associated with disease pathogenesis. We report the case of a patient developing ...

journal_title：Toxicology and applied pharmacology

authors： Kanavouras K,Tzatzarakis MN,Mastorodemos V,Plaitakis A,Tsatsakis AM

更新日期：2011-11-01 00:00:00

abstract：:Organophosphorus-ester induced delayed neurotoxicity (OPIDN) is a neurodegenerative disorder characterized by ataxia progressing to paralysis with a concomitant central and peripheral, distal axonapathy. Diisopropylphosphorofluoridate (DFP) produces OPIDN in the chicken that results in mild ataxia in 7-14 days and sev...

journal_title：Toxicology and applied pharmacology

authors： Damodaran TV,Attia MK,Abou-Donia MB

更新日期：2011-11-01 00:00:00

abstract：:Melittin is a cationic, hemolytic peptide that is the main toxic component in the venom of the honey bee (Apis mellifera). Melittin has multiple effects, including anti-bacterial, anti-viral and anti-inflammatory, in various cell types. However, the anti-apoptotic mechanisms of melittin have not been fully elucidated ...

journal_title：Toxicology and applied pharmacology

authors： Lee WR,Park JH,Kim KH,Park YY,Han SM,Park KK

更新日期：2011-10-15 00:00:00

abstract：:Both low-molecular-mass thiols (LMM-SH) and protein thiols (P-SH) can modulate the biological activity of S-nitrosothiols (RSNO) via S-transnitrosation reactions. It has been difficult to evaluate the entity of this effect in blood circulation by in vitro assays with isolated aorta rings so far, because media rich in ...

journal_title：Toxicology and applied pharmacology

authors： Giustarini D,Tsikas D,Rossi R

更新日期：2011-10-15 00:00:00

abstract：:Contamination of animal feed with mycotoxins is a major problem for fish feed mainly due to usage of contaminated ingredients for production and inappropriate storage of feed. The use of cereals for fish food production further increases the risk of a potential contamination. Potential contaminants include the mycotox...

journal_title：Toxicology and applied pharmacology

authors： Pietsch C,Bucheli TD,Wettstein FE,Burkhardt-Holm P

更新日期：2011-10-01 00:00:00